代謝疾病或症候群影響認知功能，包括記憶力、視覺空間能力、執行能力和一般認知能力。²

血壓升高或高血壓影響的大腦特定部位

研究指出血壓成為與認知表現有最強關聯性的因素，更成為代表神經退化性損傷的標誌。³

而大腦特定部位的變化是高血壓影響認知功能的關鍵，更會造成記憶力、思維能力減退及腦退化症等後果。⁴

代謝疾病/症候群如何影響認知功能

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大健康‧新趨勢 Nu Channel 素材

1. 衛生署 (2020-2022) 《衛生署人口健康調查》

2. Yates KF, Sweat V, Lai YP, et al. Impact of Metabolic Syndrome on Cognition and Brain: A Selected Review of the Literature. Arterioscler Thromb Vasc Biol. 2012; 32(9): 2060–2067. https://doi.org/10.1161/ ATVBAHA.112.252759

3. Levin BE, Llabre MM, Dong C, et al. Modeling metabolic syndrome and its association with cognition: the Northern Manhattan study. J Int Neuropsychol Soc. 2014: 20(10): 951–60. https://doi.org/10.1017/ S1355617714000861

4. Mateusz Siedlinski, Carnevale, L., Xu, X., Carnevale, D., Evangelou, E., Caulfield, M. J., Maffia, P., Wardlaw, J. M., Samani, N. J., Tomaszewski, M., Lembo, G., Holmes, M. V., & Guzik, T. J. (2023). Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure. European Heart Journal, 44(23), 2114–2125. https://doi.org/10.1093/eurheartj/ehad101‌

5. Yaffe K, Vittinghoff E, Pletcher MJ, et al. Early adult to midlife cardiovascular risk factors and cognitive function. Circulation. 2014; 129(15): 1560–7. https://doi.org/10.1161/CIRCULATIONAHA.113.004798

6. *Cavalieri M, Ropele S, Petrovic K, et al. Metabolic Syndrome, Brain Magnetic Resonance Imaging, and Cognition. Diabetes Care. 2010; 33(12): 2489–2495. https://doi.org/10.2337/dc10-0851

7. #Exalto LG, van der Flier WM, van Boheemen CJ, et al. The metabolic syndrome in a memory clinic population: relation with clinical profile and prognosis. J Neurol Sci. 2015; 351(1–2): 18–23. https://doi. org/10.1016/j.jns.2015.02.004

8. 香港大學李嘉誠醫學院 (港大醫學院) (2024年12月) 《高血糖削弱二型糖尿病患者之抗病毒免疫力》